In situ quantitative measurement of concentration profiles in a microreactor with submicron resolution using multiplex CARS microscopy

Authors
Publication date 03-09-2008
Journal Journal of the American Chemical Society
Volume | Issue number 130 | 35
Pages (from-to) 11592-11593
Organisations
  • Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
  • Faculty of Science (FNWI) - Institute of Physics (IoP) - Van der Waals-Zeeman Institute (WZI)
Abstract In situ quantitative imaging of concentration profiles of reactants and products inside a microfluidic reactor is achieved, with submicron spatial resolution with similar to mM sensitivity and on similar to ms time scales, for a given position. The label-free approach relies on quantitative vibrational spectroscopy, using Coherent Anti-Stokes Raman scattering microscopy in a spectrally resolved fashion, and is demonstrated on an elementary acid-base reaction.
Document type Article
Note With supporting info.
Language English
Published at
https://doi.org/10.1021/ja804158n (Final published version)
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