The adolescent outcome of children with Attention Deficit Hyperactivity Disorder treated with methylphenidate or methylphenidate combined with multimodal behaviour therapy: results of a naturalistic follow-up study

Objective: Children with attention deficit hyperactivity disorder (ADHD) who participated in a
randomized clinical trial, which compared a brief intensive multimodal behaviour therapy combined
with optimally titrated methylphenidate to optimally titrated methylphenidate alone (n = 45), were reassessed at adolescence in a naturalistic follow‐up 4.5 to 7.5 years after treatment. Also a matched
normal control group was recruited (n = 23).
Methods: Assessments at follow‐up included diagnostic status, ADHD symptoms, oppositional and
conduct behaviour, substance abuse symptoms and parenting stress.
Results: Of the 24 adolescents participating in the follow‐up study, 50% still met diagnostic criteria for
ADHD. There were no significant differences between adolescents at follow‐up and those lost for
follow‐up. At follow‐up, adolescents in the combined treatment condition used significantly less
medication than children in the methylphenidate condition; there were no other significant differencesbetween the treatment conditions. The adolescents showed a significant decline in hyperactivity/impulsivity, oppositional and conduct disorder symptoms from post‐test to follow‐up. Only inattention symptoms increased from post‐test to follow‐up but not to pre‐test levels. The adolescents originally diagnosed with ADHD fared significantly worse than the matched controls on all outcomes, except on conduct disorder and substance abuse symptoms.
Conclusions: Our study shows in adolescents, diagnosed with ADHD in childhood, age‐dependent
decline of ADHD symptoms, although they still fared significantly worse than matched normal
controls. Implications of results are restricted by small samples size, and the results may be subject to chance findings and need replication before firm conclusions can be drawn.