The Nur77 Narrative Resolution of Macrophage Inflammation

Nur77 is a transcription factor with anti-inflammatory properties, particularly in macrophages, and plays a big role in chronic inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, and atherosclerosis. While Nur77 has shown protective effects in autoimmune conditions, the mechanisms by which it exerts these effects are not fully understood. In this thesis, I investigate how Nur77 influences inflammation through key signaling pathways like AP-1 and NF-κB. Through using multiple (transcript)omics techniques, I found that Nur77 regulates macrophage behavior by altering cellular mechanics and modulating inflammatory signaling, presenting Nur77 as a promising candidate for therapeutic intervention in chronic inflammation.