Studies on the role of glycosphingolipids in metabolism

Thesis

Cover

Title pages

Table of contents

Chapter 1: An introduction to type I Gaucher disease

Chapter 2: Glycosphingolipids and insulin resistance

Aim and outline of the thesis

Chapter 3: Very low serum adiponectin levels in patients with type 1 Gaucher disease without overt hyperglycemia

Chapter 4: Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance

Chapter 5: Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease

Chapter 6: Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy

Chapter 7: Hypermetabolism in Gaucher disease type I is not associated with altered thyroid hormone levels

Chapter 8: Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease

Chapter 9: Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

Chapter 10: Treatment of genetically obese (ob/ob) mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin (AMP-DNM) acutely increases fat oxidation and decreases food intake

Chapter 11: Summary and general discussion

Samenvatting

Co-authors affiliations

About the author

List of publications

Dankwoord