Plasminogen activator inhibitor type 1: function in fibrinolysis and atherosclerosis

Thesis

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Titlepage

Table of Contents

Abbreviations:

Chapter 1 General Introduction

Chapter 2 Molecular Advances in Plasminogen Activator Inhibitor 1 Interaction with Thrombin and Tissue-Type Plasminogen Activator

Chapter 3 The Variable Region-1 from Tissue-Type Plasminogen Activator Confers Specificity for Plasminogen Activator Inhibitor-1 to Thrombin by Facilitating Catalysis: Release of a Kinetic Block by a Heterologous Protein Surface Loop.

Chapter 4 High-density Mutagenesis by Combined DNA Shuffling and Phage Display to Assign Essential Amino Acid Residues in Protein-protein interactions: Application to Study Structure-Function of Plasminogen Activator Inhibitor 1 (PAI-1).

Chapter 5 Different Structural Requirements for Plasminogen Activator Inhibitor 1 (PAI-1) Loop Insertion during Latency Transition and Target Proteinase Inhibition as Evidenced by Phage-Displayed Hypermutated PAI-1 Libraries.

Chapter 6 The Composition of Complexes between Plasminogen Activator Inhibitor 1, Vitronectin and Either Thrombin or Tissue-Type Plasminogen Activator.

Chapter 7 Co-localization of Thrombin, Plasminogen Activator Inhibitor 1 (PAI-1) and Vitronectin in the Atherosclerotic Vessel Wall: a Potential Regulatory Mechanism of Thrombin Activity by PAI-1/Vitronectin Complexes

Chapter 8 General Discussion

Summary/Samenvatting

Nawoord en Curriculum Vitae

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