Research Review: Siblings matter A multi-level meta-analysis on the association between cannabis use among adolescent siblings

Background: Parents' and peers' cannabis use are well-documented predictors of youth cannabis use, however, relatively little is known about the influence of siblings' cannabis use. Hence, this meta-analysis investigated the association between sibling-youth cannabis use (disorder) and explored moderation by sibling type (monozygotic- vs. dizygotic- vs. non-twins), age, age spacing, birth order, gender, and gender constellations (same- vs. mix- gender pairs). When comparison data of parents' and peers' cannabis use (disorder) were also available in the included studies, separate meta-analyses on associations between parent-youth and peer-youth cannabis use (disorder) were additionally conducted. Methods: Studies were selected if they included 11- to 24-year-old participants, and investigated associations between cannabis use (disorder) among those youth and their siblings. These studies were retrieved via a search in seven databases (e.g., PsychINFO). A multi-level meta-analysis using a random effects model was performed on the studies, and heterogeneity analyses and moderator analyses were also conducted. PRISMA guidelines were followed. Results: We retrieved 20 studies (most of which originated from Western cultures) with 127 effect sizes for the main sibling-youth meta-analysis and found a large overall effect-size (r =.423), implying that youth had higher cannabis use rates when their sibling used cannabis, and this association was stronger for monozygotic twins and for same-gender sibling pairs. Finally, a medium effect size existed for the associations between parent-youth cannabis use (r =.300) and a large effect size for peer-youth cannabis use (r =.451). Conclusions: Youth are more likely to use cannabis when their siblings use cannabis. This sibling-youth cannabis use association existed for all sibling constellations, was larger than the association between parent-youth cannabis use, and was similar in magnitude compared to the association between peer-youth cannabis use—suggesting both genetic and environmental influences (e.g., social-learning) between siblings. Hence, it is important not to neglect sibling influences when treating youth cannabis use (disorder).