MRP2-4, from drug resistance to physiology

Thesis

Cover

Titlepage

Contents

Chapter 1 Introduction

Chapter 2 Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)

Chapter 3 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3)

Chapter 4 Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the iteal Na+-dependent bile acid transporter

Chapter 5 Generation and characterization of mice lacking the multidrug resistance protein 3 (Abcc3)

Chapter 6 Steroids and bile acids are substrates of human multidrug resistance protein (MRP) 4 (ATP-binding cassette C4)

Chapter 7 The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal anti-inflammatory drugs

Conclusions and perspectives

Summary

Samenvatting

Acknowledgments

Curriculum vitae

List of publications

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