Clinical dilemmas in diagnosis and treatment of breast disease

This thesis explores various clinical dilemmas in the treatment of breast disease, focusing on the phyllodes tumor and early-stage breast cancer. The first section of this thesis focuses on the phyllodes tumor. The second section addresses challenges in early breast cancer treatment, including the use of FDG-PET/CT, selecting patients for neoadjuvant systemic treatment and selection for delayed oncoplastic surgery. The thesis concludes with the DESCARTES study protocol, investigating whether radiotherapy can be omitted for patients with pCR after neoadjuvant therapy. Overall, the thesis emphasizes the need for individualized treatment strategies to improve outcomes and address persistent clinical challenges in breast cancer care.