Dynamics of ataxin-1 in spinocerebellar ataxia type 1

Authors	H.A.G. Krol
Supervisors	C.J.F. van Noorden
Cosupervisors	E.A. Reits E.M. Hol
Award date	10-09-2009
ISBN	9789490371029
Number of pages	114
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Contents Chapter 1: General introduction Chapter 2: Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation Chapter 3: PolyQ expansion in ataxin-1 does not affect intracellular dynamics of ataxin-1-interacting proteins LANP, PQBP-1 or RBM17 Chapter 4: Interaction of ataxin-1 and protein kinase Cγ mediates their phosphorylation and cellular localization status Chapter 5: Spinocerebellar ataxia-1 : insights in the function of ataxin-1 and the significance for other polyglutamine expansion disorders Chapter 6: Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity Chapter 7: Summary / Samenvatting Acknowledgements / Dankwoord
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