Improving HIV-1 envelope glycoprotein vaccines

Authors	M. Melchers
Supervisors	B. Berkhout
Cosupervisors	R.W. Sanders
Award date	17-12-2010
ISBN	9789490371517
Number of pages	205
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Table of contents Chapter 1: General introduction Chapter 2: Antibodies to HIV-1: aiming at the right target Chapter 3: Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function Chapter 4: Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2-domain, obtained by virus evolution Chapter 5: Comparative immunogenicity of evolved V1V2-deleted HIV-1 envelope glycoprotein trimers Chapter 6: An HIV-1 envelope glycoprotein trimer with an embedded GM-CSF domain induces enhanced antibody and T cell responses Chapter 7: Protein engineering of a stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand that activates dendritic cells Chapter 8: Targeting HIV-1 envelope glycoprotein trimers to B cells enhances the induction of neutralizing HIV-1 antibodies Chapter 9: General discussion Summary Nederlandse samenvatting List of publications Curriculum vitae Dankwoord
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