Peptide bond tautomerization induced by divalent metal ions: characterization of the iminol configuration

Authors
  • R.C. Dunbar
  • J.D. Steill
  • N.C. Polfer
  • G. Berden
Publication date 07-05-2012
Journal Angewandte Chemie, International Edition
Volume | Issue number 51 | 19
Pages (from-to) 4591-4593
Number of pages 3
Organisations
  • Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
Abstract Rearranged: The attachment of gas‐phase divalent metal ions that bind as strongly as Mg2+ and transition‐metal ions to the dipeptide PhePhe results in displacement of the amide proton by the newly characterized iminol tautomerization rearrangment. More weakly coordinating ions bind in the known charge‐solvation mode. Infrared multiple‐photon dissociation spectroscopy using the free‐electron laser clearly shows the tautomeric transition.
Document type Article
Note With supplementary file
Language English
Related publication Peptide bond tautomerization induced by divalent metal ions: characterization of the iminol configuration
Published at https://doi.org/10.1002/anie.201200437 https://doi.org/10.1002/ange.201200437
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