Development and clinical applications of the time intensity curve shape analysis in dynamic contrast enhanced MRI: a pixel-by-pixel approach

Thesis

Cover

Title pages

Table of contents

Chapter 1: General introduction and outline of the thesis

Chapter 2: Pixel-by-pixel analysis of DCE-MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system

Chapter 3: Region of interest and pixel-by-pixel analysis of dynamic contrast enhanced magnetic resonance imaging parameters and time-intensity curve shapes: a comparison in chondroid tumors

Chapter 4: Perianal Crohn disease: evaluation of dynamic contrast enhanced MR imaging as an indicator of disease activity

Chapter 5: Rheumatoid synovial inflammation: pixel-by-pixel dynamic contrast enhanced MR imaging time-intensity curve shape analysis–a feasibility study

Chapter 6: Reproducibility of the gadolinium concentration measurements and of the fitting parameters of the vascular input function in the superior sagittal sinus in a patient population

Chapter 7: Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma

Chapter 8: TIC shape and model based analysis of DCE-MRI data: a comparison in patients undergoing anti-angiogenic treatment for recurrent glioma

Chapter 9: Dynamic contrast enhanced MRI in determining disease activity in perianal fistulizing Crohn's disease

Chapter 10: Summary and discussion / Nederlandse samenvatting

Appendix 1: DCE-MRI analysis package comprising pixel-by-pixel classification of time intensity curves shapes, permeability maps and Gd concentration calculation

Appendix 2: Brief summary of pharmacokinetic modelling in DCE-MRI and the problems behind it

List of abbreviations

List of publications

Acknowledgements

Curriculum vitae