B and T cell crosstalk in anti-bacterial immune responses

This thesis shows that phagocytosis of Salmonella by B cells may generate a survival niche and transport vehicle for Salmonella, but that simultaneously Salmonella-infected B cells induce an optimal anti-Salmonella response through activation of multiple arms of the adaptive immune response. The thesis thus forms a clear example of how pathogens and the eukaryotic immune system have coevolved. It enables transient survival of the pathogen within the host, while simultaneously eliciting integrated pathogen-optimized immune responses that eventually clear the pathogen while minimizing host damage.