Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin

Authors
  • R. Ueoka
  • A. Ito
  • M. Izumikawa
  • S. Maeda
Publication date 2009
Journal Toxicon
Volume | Issue number 53 | 6
Pages (from-to) 680-684
Number of pages 5
Organisations
  • Faculty of Science (FNWI)
Abstract Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase. Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle.
Document type Article
Language English
Published at https://doi.org/10.1016/j.toxicon.2009.02.008
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