Global Sensitivity Analysis for a Mathematical Model of the General Escape Theory of Suicide

This study explores a formalized dynamical systems model of the General Escape Theory of Suicide using Sobol and PAWN global sensitivity analyses. The findings highlight the importance of self-feedback loops, the effect of stressors on aversive internal states, and the interaction effects between aversive internal states and the urge to escape on suicidal ideation and non-suicidal escape behaviors. Time-dependent sensitivity analysis also reveals the long-term stability of parameter importance over time. These results hold potential for informing clinical interventions by identifying the most important influences for individual suicidal ideation.