Origin and features of mammalian chitinases

Authors	A.P. Bussink
Supervisors	J.F.M.G. Aerts
Cosupervisors	R. Boot
Award date	23-01-2009
Number of pages	291
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: General introduction and outline of the thesis Chapter 2: The biology of the Gaucher cell : the cradle of human chitinases Chapter 3: Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity Chapter 4: Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates Chapter 5: Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases Chapter 6: Marked differences in tissue-specific expression of chitinases in mouse and man Chapter 7: Detection of chitinase activity by 2-aminobenzoic acid labelling of chito-oligosaccharides Chapter 8: A single histidine residue modulates enzymatic activity in acidic mammalian chitinase Chapter 9: Enzymatic features of the human, murine and bovine chitinases : versatility in hydrolase versus transglycosylase activity Chapter 10: Summary and general discussion Addendum 1: N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides Addendum 2: Glycosphingolipid lowering aza-sugar AMP-DNM reduces protein O-GlcNAcylation without directly inhibiting O-GlcNAc-transferase Chapter 11: Nederlandse samenvatting Chapter 12: Dankwoord
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