Flucytosine: an exploration of pharmacokinetics and toxicity

A. Vermes

Flucytosine: an exploration of pharmacokinetics and toxicity

Authors	A. Vermes
Supervisors	J. Dankert
Co-supervisors	H.J. Guchelaar
Award date	10 October 2000
ISBN	9090140123 9789090140124
Number of pages	206
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Infectieziekten
Language	English
Downloads	Thesis Cover Titlepage Table of Contents General Introduction and Scope Chapter I Flucytosine: a Review of lts Pharmacology, Clinical Indications, Pharmacokinetics, Toxicity and Drug Interactions. Chapter II Simultaneous Determination of Flucytosine and Fluorouracil in Human Plasma by High-Performance Liquid Chromatography. Chapter III Population Pharmacokinetics of Flucytosine: Comparison of Three Models Using STS, NPEM and NONMEM. Chapter IV Validation of the Population Pharmacokinetic Models of Flucytosine Using NONMEM. Chapter V Flucytosine: Correlation Between Toxicity and Pharmacokinetic Parameters. Chapter VI Prediction of Flucytosine-Induced Thrombocytopenia Using Creatinine Clearance. Chapter VII An Accelerated Stability Study of Flucytosine in Intravenous Solution. Chapter VIII An In Vitro Study on the Active Conversion of Flucytosine to Fluorouracil by Microorganisms in the Human Intestinal Microflora. Chapter IX Flucytosine-Related Bone-Marrow Depression and Conversion to Fluorouracil: a Pilot Study. Chapter X General Discussion Chapter XI Summary Chapter XII Samenvatting Dankwoord CURRICULUM VITAE LIST OF PUBLICATIONS Stellingen behorend bij het proefschrift Cover
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Flucytosine: an exploration of pharmacokinetics and toxicity