Contributions of CD27 and relatives to the specific immune response

Thesis

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Titlepage

CONTENTS

Chapter 1 General Introduction

Chapter 2 CD27/CD70 interactions are not required for T cell development or selection in the thymus, but promote deletion of self-specific T cells in the periphery.

Chapter 3 CD27 is required for generation and long-term maintenance of T cell immunity.

Chapter 4 CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.

Chapter 5 CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.

Chapter 6 OX40 and 4-1BB, together with CD27, determine the amount of CD8 z memory T cells formed and imprint into them the capacity for secondary expansion.

Chapter 7 General Discussion

Summary

Samenvatting

LIST OF PUBLICATIONS

CURRICULUM VITAE

DANKWOORD

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