'From the cradle to the grave' : novel therapeutic approaches to attack the microenvironment in chronic lymphocytic leukemia

Authors	D. Hallaert
Supervisors	M.H.J. van Oers
Cosupervisors	E. Eldering
Award date	15-10-2008
Number of pages	176
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Title page Contents Chapter 1: General introduction Chapter 2: Crosstalk among Bcl-2 family members in B-CLL : seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection Chapter 3: γ-secretase inhibitor (GSI)-1 induces apoptosis in CLL cells via proteasome inhibition and Noxa upregulation Chapter 4: Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity Chapter 5: Persistent Mcl-1/Bim protein signature after CD40 ligation in chronic lymphocytic leukemia is associated with specific drug sensitivity Chapter 6: c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL : implications for therapeutic targeting of chemoresistant niches Chapter 7: Concluding remarks Chapter 8: Summary Chapter 9: Nederlandse samenvatting Dankwoord Curriculum vitae List of publications Color figures
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