Modulation of fenretinide induced cell death in neuroblastoma

Authors	R. Cuperus
Supervisors	H.N. Caron
Cosupervisors	A.B.P. van Kuilenburg G.A.M. Tytgat
Award date	07-10-2014
ISBN	9789090284538
Number of pages	163
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Neuroblastoma is a childhood tumor that, despite intensive therapy, has a poor prognosis especially in high risk patients. Therefore, new therapeutic options are needed to improve the outcome of these patients. The research described in this thesis attempts to unravel the apoptosis-inducing mechanism of fenretinide in neuroblastoma and, in order to increase its anti-tumor effects, we investigated possibilities for combination therapy.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: General introduction Chapter 2: Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids Chapter 3: Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma Chapter 4: Fenretinide induces increased levels of monolysocardiolipin in neuroblastoma Chapter 5: Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids Chapter 6: Synergistic effects of fenretinide and Hsp90 inhibitor 17AAG in neuroblastoma cells Chapter 7: Summary and future perspectives Nederlandse samenvatting Acknowlegdements Curriculum vitae List of publications Appendices
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