An innovative method to study target protein-drug interactions by mass spectrometry
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| Publication date | 2009 |
| Journal | Journal of Medicinal Chemistry |
| Volume | Issue number | 52 | 9 |
| Pages (from-to) | 2875-2879 |
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| Abstract | We report the combination of chemical cross-linking and high-resolution mass spectrometry for analyzing conformational changes in target proteins that are induced by drug binding. With this approach conformational changes in the peroxisome proliferator-activated receptor alpha (PPARα) upon binding of low-molecular weight compounds were readily detected, proving that the strategy provides a basis to efficiently characterize target protein−drug interactions. |
| Document type | Article |
| Published at |
https://doi.org/10.1021/jm9000665
(Final published version)
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