Juvenile polyposis : aspects of molecular genetics and histology on the pathogenesis of a precancerous syndrome

Authors	W.A. van Hattem
Supervisors	G.J.A. Offerhaus F.J.W. ten Kate
Cosupervisors	W.W.J. de Leng
Award date	17-04-2009
ISBN	9789071382871
Number of pages	119
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Table of contents Chapter one: General introduction and outline of the thesis Chapter two: Gastrointestinal polyposis syndromes Chapter three: Risk of colorectal cancer in juvenile polyposis Chapter four: Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis Chapter five: No TGFBRII germline mutations in juvenile polyposis patients without SMAD4 or BMPR1A mutation Chapter six: Histological variations in juvenile polyp phenotype : a link to patient genotype Chapter seven: SMAD4 protein expression in polyps of juvenile polyposis mirrors genetic status but does not reflect neoplastic progression Chapter eight: Increased cyclooxygenase-2 expression in juvenile polyposis Chapter nine: Summary and concluding remarks Chapter ten: Nederlandse samenvatting Acknowledgements Publications
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