From stem cell to platelet

From stem cell to platelet

Authors	M.R. Tijssen
Supervisors	C.E. van der Schoot D. Roos
Cosupervisors	C. Voermans J.J. Zwaginga
Award date	15-01-2008
ISBN	9789090226293
Number of pages	151
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Titlepage Contents Preface: Scope of this thesis Chapter 1: Clinical approaches involving thrombopoietin, to shorten the period of thrombocytopenia after high-dose chemotherapy Chapter 2 Improved post-thaw viability and in vitro functionality of peripheral blood hematopoietic progenitor cells after cryopreservation with a theoretically optimized freezing curve Chapter 3: Transplantation of human peripheral blood CD34-positive cells in combination with ex vivo expanded megakaryocytes results in fast platelet formation in NOD/SCID mice Chapter 4: The (patho)physiology of megakaryocytopoiesis: from thrombopoietin in diagnostics and therapy to ex vivo generated cellular products Chapter 5: Functional analysis of single amino-acid mutations of the Tpo receptor MPL underlying congenital amegakaryocytic thrombocytopenia Chapter 6: Juvenile cyclic amegakaryocytic thrombocytopenia, a novel entity Chapter 7: Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins Chapter 8: Thrombopoietin stimulates endothelial integrity Chapter 9: Summary and general discussion Nederlandse samenvatting Dankwoord List of publications
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From stem cell to platelet