Enteroendocrine cells the gatekeepers of microbiome-gut-brain communication

Open Access
Authors
Publication date 01-09-2025
Journal npj Biofilms and Microbiomes
Article number 179
Volume | Issue number 11
Organisations
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Abstract Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.
Document type Review article
Language English
Published at https://doi.org/10.1038/s41522-025-00810-x
Other links https://www.scopus.com/pages/publications/105014915269
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Enteroendocrine cells (Final published version)
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