Clinical and laboratory studies in genetic and acquired prothrombotic states

Thesis

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Stellingen

Titlepage

Contents

Chapter 1 Introduction

PART I Clinical studies in genetic prothrombotic states

Chapter 2 Familial thrombophilia

Chapter 3 Approach to the thrombophilic patient

Chpter 4 The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis

Chapter 5 A prospective study on the incidence of clinically overt venous thromboembolism in asymptomatic carriers of the factor V Leiden mutation

Chapter 6 Increased risk for fetal loss in carriers of the factor V Leiden mutation

Chapter 7 Venous thromboembolism in heterozygous carriers of factor V Leiden: Contribution of the protrombon 20210A and other concomitant genetic and exognous risk factors

Chapter 8 Factor XIII Val34Leu and the risk for venous thromboembolism in factor V Leiden carriers

Chapter 9 The incidence of venous thromboembolism in relatives of patients with the prothrombin 20210A mutation

Chapter10 Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis

PART II Laboratory studies in acquired prothrombotic states

Chapter 11 Oral contraceptives and hormonal replacement therapy cause an imbalance in coagulation and fibrinolysis which may explain the increased risk of venous thromboembolism

Chapter 12 Acquired APC resistance and oral contraceptives: a randomised cross-over study of two low dose oral contraceptives

Chapter 13 Effects on coagulation of levonorgestrel- and desogestrel- containing low dose oral contraceptives: a cross-over study

Chapter 14 Effect of oral contraceptives on the fibrinolytic system: a randomized cross-over study of two low-dose oral contraceptives

Chapter 15 A randomized cross-over study on the effects of levonorgestrel-and desogestrel-containing oral contraceptives on the anticoagulant pathways

Summary

Samenvatting

Co-authors

Dankwoord

Curriculum Vitae

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