Evaluation of adenoviral vectors as vaccine for malaria

Cover

Titlepage

Contents

Chapter 1: Introduction

1.1: General introduction (Res. adv. in virology)

1.2: Scope of this thesis

Chapter 2: Technical advance in vector and antigen selection

2.1: An adenoviral type 5 vector carrying a type 35 fiber as a vaccine vehicle: DC targetting, cross neutralization and immunogenicity (Vaccine)

2.2: Expression and immunogenicity of the Plasmodium falciparum circumsporozoite protein: The role of GPI signal sequence (Vaccine)

Chapter 3: Adenovirus based candidate malaria vaccines

3.1: Immunogenicity and protection of a recombinant human adenovirus serotype 35 based malaria vaccine against Plasmodium yoelii in mice (Infection and Immunity)

3.2: Increased immunogenicity of recombinant Ad35-based malaria vaccine through formulation with Aluminium phosphate adjuvant (Vaccine)

Chapter 4: Conclusion

4.1: Summary and conclusion

4.2 Summary and conclusion in Dutch

4.3 Curriculum Vitae

List of publications

Acknowledgement