Tumor modeling in mice with conditional retinoblastoma gene deficiency

Authors	M.A.G.G. Vooijs
Supervisors	A.J.M. Berns
Award date	07-12-2001
Number of pages	108
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: NKI
Downloads	Thesis Cover Titlepage Contents Chapter 1 Developmental defects and tumor predisposition in Rb mutant mice. Chapter 2 Cre-mediated somatic site-specific recombination in mice. Chapter 3 Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Chapter 4 Tumorigenesis in mice after somatic deletion of Rb in Interphotoreceptor Retinol Binding Protein-expressing cells. Chapter 5 A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. Chapter 6 Non-invasive imaging of spontaneous Rb pathway dependent tumor development in mice. General discussion and summary Samenvatting Abbreviations Curriculum Vitae Publications Dankwoord Cover
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