Observations in clinical and experimental ocular autoimmunity

Thesis

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Titlepage

Table of Content

Outline of the thesis

Introduction

Chapter 1 Regulation of Ocular Inflammation, What Experimental and Human Studies Have Taught Us

Section I: Analysis of Immunologie Determinants to Ocular Autoantigens in Experimental Models

Chapter 2 Analysis of the Pivotal Residues of the Immunodominant and Highly Uveitogenic Determinant of Interphotoreceptor Retinoid-Binding Protein

Chapter 3 Indentification of Heat Sock Proteins Binding to an Immunodominant Uveitopathogenic Peptide of IRBP

Chapter 4 Human S-Antigen: Presence of Multiple Immunogenic and Immunopathogenic Sites in the Lewis Rat

Chapter 5 Immunogenicity and Pathogenicity of Human S-Ag Determinants in Rat Strains

Section II: Immunologic Responses to Ocular Autoantigens in Humans

Chapter 6 Cellular Immune Responses of Patients with Uveitis to Retinal Antigens and teir Fragments

Chapter 7 A Novel Method for the Determination of T-cell Profliferative Responses in Patients with Uveitis

Chapter 8 Prospective Determination of T cell Responses to S-Antigen in Behçet's Disease Patients and Controls

Chapter 9 Human S-Antigen Determinant Recognition in Uveitis Patients

Section III: Novel Therapeutic Strategies in Uveitis

Chapter 10 FK506 Treatment of Experimental Autoimmune Uveoretinitis in Primates

Chapter 11 Treatment of Autoimmune Uveoretinitis in the Rat with Rapamycin, an Inhibitor of Lymphocyte Growth Factor Signal Transduction

Chapter 12 Treatment of Uveitis with Recombinant Human Interleukin-13

Section IV: Therapeutic Strategies for the Treatment of Human Uveitis

Chapter 13 Clinical Use of Cyclosporine in Ocular Disease

Chapter 14 Combined Use of Cyclosporine and Ketoconazole in the Treatment of Endogenous Uveitis

Chapter 15 Long Term Follow-up of Patients with Endogenous Uveitits Treated with Combination Ccyclosporine and Ketoconazole

Chapter 16 Intraocular Inflammatory Disease (Uveitis) and the Use of Oral Tolarance: A Status Report

Summary and Conclusions

Samenvatting en Conclusies

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