SIAPhos: phosphorylated sulfonimidamides and their use in iridium-catalyzed asymmetric hydrogenations of sterically hindered cyclic enamides
| Authors |
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| Publication date | 2012 |
| Journal | Advanced Synthesis & Catalysis |
| Volume | Issue number | 354 | 1 |
| Pages (from-to) | 59-64 |
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| Abstract | Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P-N-S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee). |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1002/adsc.201100692
(Final published version)
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