Clearance of intracellular aggregation-prone protein fragments

Authors	J.M.E.P. Gillis
Supervisors	C.J.F. van Noorden
Cosupervisors	E.A. Reits
Award date	18-11-2009
ISBN	9789490371074
Number of pages	161
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: Introduction Chapter 2: Peptidase-resistant proteasomal products are sequestered into lysosomes and subsequently degraded Chapter 3: Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity Chapter 4: Hsp40 family members assist in clearance of aggregate-initiating polyglutamine peptides Chapter 5: Chaperones affect intermolecular interactions between aggregated polyQ peptides Chapter 6: Amyloid-β is efficiently degraded in the cytoplasm Chapter 7: Intracellular clearance of toxic fragments in neurodegenerative diseases Summary Samenvatting Dankwoord Publication list Curriculum vitae Abbreviation list
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