Fundamental studies on radiotracers intended for receptor imaging in dementia

Thesis

Cover

Title page

Contents

Chapter 1: Introduction, aims and outline of the thesis

Chapter 2: Synthesis and evaluation of iodinated TZTP-derivatives as potential radioligands for imaging of muscarinic M2 receptors with SPECT

Chapter 3: Synthesis and in-vitro evaluation of novel nortropane derivatives as potential radiotracers for muscarinic M2 receptors

Chapter 4: In-vitro and ex-vivo storage phosphor imaging of short-living radioisotopes

Chapter 5: In-vivo [123I]CNS-1261 binding to D-serine activated and MK801 blocked NMDA receptors : a storage phosphor imaging study in rats

Chapter 6: No significant effects of single intravenous, single oral and subchronic oral administration of acetylcholinesterase inhibitors on striatal [123I]FP-CIT binding in rats

Chapter 7: The effects of repeated administration of neuroleptics on muscarinic receptor binding in rat brain, as measured by [123I]Iododexetimide

Chapter 8: Decreased ipsilateral [123I]Iododexetimide binding to cortical muscarinic receptors in unilaterally 6-hydroxydopamine lesioned rats

Chapter 9: Decreased cortical muscarinic receptor density in PDD vs PD patients as assessed by in-vivo [123I]Iododexetimide SPECT

Chapter 10: Summary

Chapter 11: General discussion and conclusions

Chapter 12: Samenvatting

Chapter 13: Algemene discussie en conclusies

Dankwoord

Appendix: Color figures