Microenvironmental regulation of multiple myeloma and malignant lymphoma: the role of HGF, Wnts, heparan sulfate proteoglycans, and N-cadherin

Authors	R.W.J. Groen
Supervisors	S.T. Pals
Cosupervisors	M. Spaargaren
Award date	18-11-2010
ISBN	9789090257686
Number of pages	201
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Table of contents Chapter 1: General introduction Chapter 2: Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B cell lymphoma Chapter 3: Illegitimate Wnt pathway activation by β-catenin mutation or autocrine stimulation in T cell malignancies Chapter 4: Transcriptional silencing of the Wnt-antagonist Dickkopf-1 by promoter methylation unleashes aberrant Wnt signaling in advanced multiple myeloma Chapter 5: A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve graft versus myeloma Chapter 6: Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma Chapter 7: N-cadherin-mediated adhesion of multiple myeloma cells inhibits osteoblast differentiation Chapter 8: General discussion Summary Nederlandse samenvatting Dankwoord Curriculum vitae Publications by the author
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