Who needs adjuvant systemic treatment? Predicting prognosis in node-negative breast cancer; from bench to bedside

Thesis

Front page

Title pages

Contents

Chapter 1: Introduction & outline thesis : prognostic factors and clinical guidelines for adjuvant systematic treatment in node-negative breast cancer

Chapter 2: Tuning into the genetic orchestra using microarrays : limitations of DNA microarrays in clinical practice

Chapter 3: Validation of 70-gene prognosis signature in node-negative breast cancer

Chapter 4: Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer : a prospective community-based feasibility study (RASTER)

Chapter 5: Reflection and reactions : are gene signatures better than traditional clinical factors?

Chapter 6: Adherence to clinical guidelines in node-negative breast cancer in the Netherlands (1998-2006)

Chapter 7: The impact of inter-observer variation in pathological assessment of node-negative breast cancer on clinical risk assessment and patient selection for adjuvant systemic treatment

Chapter 8: Additional value and potential use of 70-gene prognosis signature in node-negative breast cancer in daily clinical practice

Chapter 9: Summary / Samenvatting

Appendix: Constructive Technology Assessment (cta) as a tool in Coverage with Evidence Development : the case of the 70-gene prognosis signature for breast cancer diagnostics

Dankwoord

List of publications

Curriculum vitae

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