2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes

2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A₁, A_2A and A₃ receptor subtypes

Authors	M.J. Wanner J.C. Von Freitag Drabbe Kunzel A.P. IJzerman G.J. Koomen
Publication date	2000
Journal	Bioorganic & Medicinal Chemistry Letters
Volume \| Issue number	10 \| 18
Pages (from-to)	2141-2144
Organisations	Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
Abstract	The influence of nitro substituents on the properties of adenosine and 1-deazaadenosine was studied. Combination of a nitro group at the 2-position with several N⁶ substituents such as cyclopentyl and m-iodobenzyl gave a series of analogues with good adenosine receptor affinity, showing directable selectivity for the A₁, A_2A and A₃ adenosine receptor subtypes.
Document type	Article
Language	English
Published at	https://doi.org/10.1016/S0960-894X(00)00415-7
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