Apolipoproteins A-I and A-V as gene therapeutic targets to intervene in lipid metabolism

Authors	S.F.C. Vaessen
Supervisors	J.J.P. Kastelein
Cosupervisors	J.A. Kuivenhoven F.G. Schaap
Award date	17-09-2009
ISBN	9789090245225
Number of pages	188
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 General introduction and outline of thesis Chapter 2 Gene therapy in disorders of lipoprotein metabolism Chapter 3 AAV gene therapy as a means to increase apolipoprotein A-I and high-density lipoproteincholesterol levels: Correction of murine apoA-I deficiency Chapter 4 Moderate AAV-mediated expression of human apolipoprotein A-I in LDLr-/- mice induces a decrease in endogenous murine apolipoprotein A-I levels and results in atherosclerosis progression Chapter 5 Lethal toxicity upon AAV-mediated green fluorescent protein expression in bone marrow transplanted mice precluded investigation of the cholesterol-efflux independent atheroprotective effects of apoA-I Chapter 6 Apolipoprotein A-V, triglycerides and risk of future coronary artery disease in apparently healthy men and women; the prospective Epic- Norfolk population study Chapter 7 Plasma apolipoprotein A-V levels in mice are positively associated with plasma triglyceride levels Chapter 8 Efficient lowering of triglyceride levels in mice by human apoA-V protein variants associated with hypertriglyceridemia Chapter 9 General discussion and implications Abstract/Samenvatting Dankwoord Curriculum Vitae Stellingen
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