Inflammation in ischemia and reperfusion: From mice to men

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders, the desire for enhanced knowledge on immunological and inflammatory processes to guide the development of novel immunomodulatory strategies has grown dramatically. In this thesis, inflammatory mediators of ischemia and reperfusion injury in small bowel and liver injury are investigated. As a prime initiator and important modulator of immunological and inflammatory processes, the complement system has emerged as an attractive target for early and upstream intervention in inflammatory diseases. In this thesis animal models of complement-mediated ischemia and reperfusion are employed and examples of translation into the human clinical setting are explored.