Synthesis of strained cyclic peptides via an aza-Michael-acyl-transfer reaction cascade
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| Publication date | 2012 |
| Journal | Chemical Communications |
| Volume | Issue number | 48 |
| Pages (from-to) | 8084-8086 |
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| Abstract | A new method is presented to prepare strained lactams. Esterification of the C-terminus of a dipeptide with β-nitrostyrene or quinoline-type auxiliaries is followed by lactam formation by an intramolecular aza-Michael-acyl-transfer reaction cascade. Ultimately, the cyclic tetrapeptide cyclo[Phe-Tyr-Ala-Gly] has been prepared. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1039/c2cc34121b
(Final published version)
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