Mutational profiling of glioblastoma

Authors	F.E. Bleeker
Supervisors	W.P. Vandertop C.J.F. van Noorden
Cosupervisors	S Leenstra A. Bardelli
Award date	19-06-2009
ISBN	9789090243108
Number of pages	176
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Title pages Contents Chapter 1: Introduction, aim and outline Chapter 2: Genomic landscapes of cancers : prospects for targeted therapies Chapter 3: Mutational profiling of kinases in glioblastoma Chapter 4: Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma Chapter 5: Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes Chapter 6: AKT1E17K in human solid tumors Chapter 7: Absence of AKT1 mutations in glioblastoma Chapter 8: PLXNB1 mutations in human cancer Chapter 9: IDH1R132 mutations occur frequently in high-grade gliomas but not in other solid tumors Chapter 10: IDH1 mutated glioblastomas display improved survival and reduced NADP+-dependent IDH activity ex vivo Chapter 11: Recent advances in the molecular understanding of glioblastoma Chapter 12: General discussion Chapter 13: Summary Chapter 14: Nederlandse samenvatting Sequenced genes Supplementary tables Abbreviations List of publications Dankwoord Curriculum vitae
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