Use of localized gene transfer to develop novel treatment strategies for the salivary component of Sjögren's syndrome

Thesis

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Titlepage

CONTENTS

1 General introduction

2 Use of localized gene transfer to develop novel treatment strategies for the salivary component of Sjögren's syndrome

3 Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics

4 Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors

5 Enhanced transduction of mouse salivary gland with AAV5 based vectors

6 Local AdenoAssociated VirusMediated Interleukin 10 Gene Transfer Has DiseaseModifying Effects in a Murine Model of Sjögren's syndrome

7 Disease modifying effects of local soluble tumor necrosis factor receptor-1 gene transfer in a murine model of Sjögren's syndorme

8 Summary and discussion

Samenvatting

ACKNOWLEDGEMENTS

CURRICULUM VITAE

BIBLIOGRAPHY

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