Infectious diseases and fibrotic disorders: Potential novel targets

Cover

Title pages

Contents

Preface: General introduction (and outline thesis)

Chapter 1: CCAAT/enhancer binding protein δ: Friend or foe in inflammation?

Chapter 2: CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

Chapter 3: CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: Potential role for macrophage migration

Chapter 4: CCAAT/enhancer-binding protein δ: Multifaceted regulator in respiratory disease

Chapter 5: CCAAT/enhancer-binding protein delta (C/EBPδ) plays a minor role in renal host defense against uropathogenic Escherichia coli

Chapter 6: CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy

Chapter 7: Protease Activated Receptors (PARs) in fibroproliferative disease

Chapter 8: Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

Chapter 10: Protease activated receptor-1 (PAR-1) deficiency ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma

Chapter 11: PAR-2 drives proliferation and extra cellular matrix deposition of dermal fibroblasts and promotes skin fibrosis during experimental scleroderma

Chapter 12: General discussion and summary

Nederlandse samenvatting

Dankwoord

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