On the trail of innate immune responses: Plasmacytoid dendritic cells and beyond

Authors	M. Balzarolo
Supervisors	J.P. Medema
Cosupervisors	M.C. Wolkers
Award date	04-09-2013
ISBN	9789461823120
Number of pages	155
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Our study sheds new light on pDCs development and function, and might provide new clues for optimizing infection and cancer therapy by harnessing pDC cytotoxicity through TRAIL. Furthermore, this study provides interesting clues to understand the innate immune responses towards bacterial nucleic acids and for the development of new therapeutic and vaccination strategies in related immune diseases.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Table of contents Preface Chapter 1: Introduction Chapter 2: The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the anti-apoptotic gene BCL2-A1 Chapter 3: The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs Chapter 4: NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human natural killer cells Chapter 5: NAB2 and EGRs: A balanced life Chapter 6: Adenine methylation in conserved GATC motifs modulates macrophage and dendritic cell activation Chapter 7: Discussion English summary Nederlandse samenvatting Riassunto Dankwoord Curriculum vitae List of publications
Permalink to this page

Back

UvA-DARE