Hypertrophic cardiomyopathy: towards an optimal strategy

Thesis

Cover

Title pages

Table of contents

1.1: Hypertrophic cardiomyopathy

1.2: Scope and outline of this thesis

2.1: ESCAPE-HCM study: Evaluation of SCreening of Asymptomatic PatiEnts with Hypertrophic CardioMyopathy: study design, objectives and expected results

2.2: Risk factors for sudden cardiac death and follow-up in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers

2.3: How to screen asymptomatic hypertrophic cardiomyopathy mutation carriers: a cost-effectiveness analysis

3.1: Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: systematic review of clinical risk markers

3.2: The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening

3.3: Risk stratification for sudden cardiac death in hypertrophic cardiomyopathy: Dutch cardiologists and the care for mutation carriers

3.4: Ventricular fibrillation in MYH7-related hypertrophic cardiomyopathy before onset of ventricular hypertrophy

3.5: Septum thickness in Dutch MYBPC3 mutation carriers is influenced by the M235T-AGT polymorphism, increasing age, and male sex

4.1: Uptake of genetic counselling and predictive DNA testing in hypertrophic cardiomyopathy

4.2: Quality of life and psychological distress in hypertrophic cardiomyopathy mutation carriers: a cross-sectional cohort study

4.3: Genetic counseling and cardiac care in predictively tested hypertrophic cardiomyopathy mutation carriers: the patients’ perspective

4.4: Obtaining insurance after DNA diagnostics: a survey among hypertrophic cardiomyopathy mutation carriers

5: General discussion: clinical and research perspectives

Summary

Samenvatting

Dankwoord

Curriculum vitae

List of publications