Host and viral factors in AIDS pathogenesis

Thesis

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Titlepage

Contents

chapter 1 Introduction

chapter 2 Association between an interleukin-4 promotor polymorphism and the acquisition of syncytium inducing CXCR4 using human immunodeficiency virus type 1 variants

chapter 3 Lack of evidence for an association between polymorphism in CX3CR1 and clinical course of HIV infection or virus phenotype evolution

chapter 4 Decreasing sensitivity of ß-chemokine neutralization of CCR5-using, Non-Syncytium Inducing virus variants in the course of Human Immunodeficiency Virus type 1 infection

chapter 5 Increased in-vitro Cytopathicity of CCR5 restricted Human Immunodeficiency Virus type 1 primary isolates correlates with a progressive clinical course of infection

chapter 6 Cytopathicity of Human Immuno-deficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status

chapter 7 Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immuno-deficiency Virus Type 1 Variants on Different CD4+ -T-Cell Subsets Are Determined Only by Coreceptor Expression

chapter 8 General Discussion

Summary

Samenvatting

List of publications

Dankwoord

Stellingen behorende bij het proefschrift

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