The role of CD151 and integrin α3β1 in the pathophysiology of kidney and skin

Authors	L.N. Sachs
Supervisors	A.J.M. Berns
Cosupervisors	A. Sonnenberg
Award date	16-04-2013
ISBN	9789090274317
Number of pages	150
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	In this thesis we highlight the important role of cell adhesion in the pathophysiology of skin and kidney. We particularly address the role of α3β1-CD151-complexes in podocytes during blood filtration and in keratinocytes during tumor formation.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Front cover Title pages Table of contents Preface Chapter 1: Cell–matrix adhesion of podocytes in physiology and disease Chapter 2: Kidney failure in mice lacking the tetraspanin CD151 Chapter 3: Blood pressure influences end-stage renal disease of CD151 knockout mice Chapter 4: Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells Chapter 5: Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151 Chapter 6: General discussion Summary Samenvatting (Dutch summary) Zusammenfassung (German summary) Curriculum vitae List of publications Acknowledgements Propositions
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