Fitness landscapes of gene regulation in variable environments

Authors	F.J. Poelwijk
Supervisors	D. Frenkel
Cosupervisors	S.J. Tans
Award date	29-05-2008
ISBN	9789090230597
Number of pages	184
Organisations	Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title page Contents Chapter 1: Introduction Chapter 2: Empirical fitness landscapes reveal accessible evolutionary paths Chapter 3: Evolutionary potential of a duplicated repressor-operator pair Chapter 4: Adaptive landscapes of gene regulatory systems in variable environments Chapter 5: Identification of functional mutations and epistasis by reverse neutral evolution Chapter 6: Maintenance and loss of gene regulation in experimental evolution Chapter 7: Residual affinity of induced repressors alters the shape of the induction curve Chapter 8: Reciprocal sign epistasis and multiple peaks in the fitness landscape A: Historical lineage of strains DH5®, DH10B, andMC1061 B Incompatibility of the lacZ® marker with pBR322 plasmids Bibliography Summary Samenvatting Publications Dankwoord Curriculum Vitae
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