On the unusual heme group of myeloperoxidase

Thesis

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Titlepage

Contents

Abbreviations

Chapter 1: General introduction

Chapter 2: Difference Fourier transform infrared evidence for ester bonds linking the haem group in myeloperoxidase, lactoperoxidase, and eosinophil peroxidase

Chapter 3: Characterisation of the Asp94 and Glu242 mutants in myeloperoxidase, the residues linking the haem group via ester bonds

Chapter 4: Site-directed mutagenesis of Met243, a residue of myeloperoxidase involved in binding of the prosthetic group

Chapter 5: The sulphonium ion linkage in myeloperoxidase: direct spectroscopic detection by isotopic labelling and effect of mutation

Chapter 6: The Met243 sulphonium ion linkage is responsible for the anomalous magnetic circular dichroism and optical spectral properties of myeloperoxidase

References

Summary

Samenvatting

Curriculum vitae

List of publications

Dankwoord

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