Artificial metalloenzymes through cysteine-selective conjugation of phosphines to photoactive yellow protein
| Authors |
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| Publication date |
2010
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| Journal |
ChemBioChem
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| Volume | Issue number |
11 | 9
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| Pages (from-to) |
1236-1239
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| Organisations |
-
Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
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| Abstract |
Pinning phosphines on proteins: A method for the cysteine-selective bioconjugation of phosphines has been developed. The photoactive yellow protein has been site-selectively functionalized with phosphine ligands and phosphine transition metal complexes to afford artificial metalloenzymes that are active in palladium-catalysed allylic nucleophilic substitution reactions.
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| Document type |
Article
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| Language |
English
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| Published at |
https://doi.org/10.1002/cbic.201000159
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