Chemokine receptor signals: role in migration, invasion and cancer metastasis

Authors	I.S. Zeelenberg
Supervisors	A.J.M. Berns
Cosupervisors	E. Roos
Award date	25-05-2004
Number of pages	135
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: NKI
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Introduction Chapter 2 Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma. Chapter 3 Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. Chapter 4 Blocking G-protein ßy dimers reduces desensitization of CXCR4. causing enhanced and persistent migration, independent of Pl3-kinase. Chapter 5 Fusion of docked vesicles, driven by synaptotagmin, is required for chemokine-induced T-cell migration. Chapter 6 The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases Chapter 7 A putative role for the chemokine receptor CXCR5 in tumor growth of colon carcinoma cells. Summary Samenvatting Dankwoord Curriculum vitae Other Cover
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