The acid pocket, hiatal hernia and TLESRs : essential players in the pathogenesis of gastro-esophageal reflux disease

Thesis

Cover

Title pages

Table of contents

Chapter 1: General introduction

Chapter 2: Differences in compliance of the esophagogastric junction between healthy subjects, GERD patients and patients after a Nissen fundoplication

Chapter 3: Stepwise radiofrequency ablation of Barrett’s esophagus preserves esophageal inner diameter, compliance and motility

Chapter 4: Scintigraphic imaging of the acid pocket: an enlarged pocket with acid coating the distal esophagus in GERD patients with hiatal hernia

Chapter 5: The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and GERD patients

Chapter 6: The role of GABAA receptors in the control of transient lower oesophageal sphincter relaxations in the dog

Chapter 7: Effect of Δ9-tetrahydrocannabinol, a cannabinoid receptor agonist on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans

Chapter 8: The GABAB receptor agonist AZD9343 inhibits transient lower esophageal sphincter relaxations and acid reflux in healthy volunteers : a phase I trial

Chapter 9: Does the presence of a hiatal hernia affects the efficacy of the reflux inhibitor baclofen?

Chapter 10: Summary and conclusions

Samenvatting en conclusies

Colour figures

Dankwoord

Curriculum vitae