The effect of mutant ubiquitin on proteasome function in relation to neurodegenerative disease

Authors	P. van Tijn
Supervisors	D.F. Swaab
Cosupervisors	D.F. Fischer F.W. van Leeuwen
Award date	07-11-2008
Number of pages	224
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Chapter 1: www.elsevier.com/locate/inca/412 . Chapter 2: http://jcs.biologists.org . Chapter 3: www.elsevier.com/locate/neuaging. Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter I: General introduction Chapter II: Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease Chapter III: Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin Chapter IV: Low levels of mutant ubiquitin are degraded by the proteasome in vivo Chapter V: Alzheimer-associated mutant ubiquitin impairs spatial reference memory Chapter VI: Mutant ubiquitin decreases amyloid-β deposition in a transgenic mouse model of Alzheimer's disease Chapter VII: General discussion References Color figures Summary Samenvatting List of publications Dankwoord Curriculum vitae
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